Testing & Diagnostics

Complete Blood Count (CBC)

A blood test measuring red cells, white cells, and platelets. The CBC detects anemia, infection, immune disease, and bleeding disorders — a core component of annual wellness panels for dogs.

A complete blood count (CBC) measures the cellular components of blood across three lineages: red blood cells, white blood cells, and platelets. It is one of the two fundamental blood tests in veterinary medicine (the other being the serum chemistry panel).

CBC Components

Red Blood Cell Parameters

ParameterWhat It MeasuresClinical Significance
PCV/Hematocrit% of blood volume that is red cellsLow = anemia; high = dehydration or polycythemia
Hemoglobin (Hgb)Oxygen-carrying protein concentrationParallel to PCV; both low in anemia
RBC countNumber of red cells per µLContext for PCV and Hgb
MCVMean cell volume (size)Low = iron-deficiency; high = regenerative anemia
MCHCMean cell hemoglobin concentrationLow = iron-deficiency; high = hemolysis
ReticulocytesImmature red cellsElevated = bone marrow responding to anemia (regenerative)

White Blood Cell Parameters

Cell TypeNormal FunctionElevation Suggests
NeutrophilsBacterial killingInfection, inflammation, steroid response
LymphocytesImmune responseViral infection, chronic disease, lymphoma
MonocytesTissue macrophage precursorChronic inflammation, fungal infection
EosinophilsAllergy, parasite responseParasites, allergic disease
BasophilsRare; hypersensitivity reactionsAllergy, mast cell disease

Platelets

Platelets (thrombocytes) are critical for clotting. Low platelet counts (thrombocytopenia) cause bleeding tendencies. Very low counts (<30,000/µL) carry risk of spontaneous hemorrhage.

When a CBC Is Needed

  • Annual wellness screening (all dogs)
  • Pre-anesthetic screening
  • Evaluation of lethargy, pale gums, bleeding, weight loss
  • Monitoring during chemotherapy (bone marrow suppression)
  • Any time systemic illness is suspected