Complete Blood Count (CBC)
A blood test measuring red cells, white cells, and platelets. The CBC detects anemia, infection, immune disease, and bleeding disorders — a core component of annual wellness panels for dogs.
A complete blood count (CBC) measures the cellular components of blood across three lineages: red blood cells, white blood cells, and platelets. It is one of the two fundamental blood tests in veterinary medicine (the other being the serum chemistry panel).
CBC Components
Red Blood Cell Parameters
| Parameter | What It Measures | Clinical Significance |
|---|---|---|
| PCV/Hematocrit | % of blood volume that is red cells | Low = anemia; high = dehydration or polycythemia |
| Hemoglobin (Hgb) | Oxygen-carrying protein concentration | Parallel to PCV; both low in anemia |
| RBC count | Number of red cells per µL | Context for PCV and Hgb |
| MCV | Mean cell volume (size) | Low = iron-deficiency; high = regenerative anemia |
| MCHC | Mean cell hemoglobin concentration | Low = iron-deficiency; high = hemolysis |
| Reticulocytes | Immature red cells | Elevated = bone marrow responding to anemia (regenerative) |
White Blood Cell Parameters
| Cell Type | Normal Function | Elevation Suggests |
|---|---|---|
| Neutrophils | Bacterial killing | Infection, inflammation, steroid response |
| Lymphocytes | Immune response | Viral infection, chronic disease, lymphoma |
| Monocytes | Tissue macrophage precursor | Chronic inflammation, fungal infection |
| Eosinophils | Allergy, parasite response | Parasites, allergic disease |
| Basophils | Rare; hypersensitivity reactions | Allergy, mast cell disease |
Platelets
Platelets (thrombocytes) are critical for clotting. Low platelet counts (thrombocytopenia) cause bleeding tendencies. Very low counts (<30,000/µL) carry risk of spontaneous hemorrhage.
When a CBC Is Needed
- Annual wellness screening (all dogs)
- Pre-anesthetic screening
- Evaluation of lethargy, pale gums, bleeding, weight loss
- Monitoring during chemotherapy (bone marrow suppression)
- Any time systemic illness is suspected
Related Reading
- IMHA in Dogs: Early Recognition and Relapse Monitoring
- Dog Cancer: Early Signs, Diagnosis & Treatment Guide
- IMHA in Dogs: Early Recognition and Relapse Monitoring
- Annual Wellness Testing Protocol for Dogs: Age-Based Cadence
- Longevity Bloodwork Interpretation
- Serum Chemistry Panel
- Urinalysis